Module 3 : Teaching for Learning

Author:	Mohammad Mohammad  Antigen Recognition by T lymphocytes Aim: Studying this unit, student will understand the way how T lymphocytes recognise an antigen and how this process differ from antibody recognition of antigens.
Learning Outcome:	After studying this unit you will be able to : - Diffrentiate between T-lymphocyte receptor and Fab fragment of immunoglobulin. - Major histocompatibility complex (MHC) structure and contribution in the process of antigen recognition by T lymphocytes. - Ways and mechanisms of peptide anchoring to MHC. - The importance of accessory molecules in this process. - Understanding experiments aimed at delineating this process.
Learning Activity:	- Class lecture on the structure and genetics of MHC molecule. (25 mins). - Youtube video explaining the mechanism of antigen processing and expression in the context of MHC. - Summarise the similarities and differences between T lymphocyte receptos and the Fab fragment of immunoglobulin. - List key steps in establishing a successful recognition of an antigen. - Designing an experiment to investigate the importance of accessory molecules in activation of T lymphocytes.
Assessment Task:	- Online quiz completed individually. - group of 2 working on annotating diagrams explaining the process. - Listing 3 disorders of poor/over antigen recognition.
Resources:	- online student texts and other online resources (Janway's Immunbiology, 2014). - Recent research articles addressing this lecture. - Presentation slides.